Microwave-Promoted Facile and Rapid Solvent-Free Synthesis Procedure for the Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Using ZrO2/SO42- as a Reusable Heterogeneous Catalyst

Title: Microwave-Promoted Facile and Rapid Solvent-Free Synthesis Procedure for the Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Using ZrO2/SO42- as a Reusable Heterogeneous Catalyst

Volume: 3 Issue: 6

Author(s): Muthuvel R. Ezhilarasi, Ramalingam Govindaraju, Jeyaraman Thanusu, Vijayakumar Kanagarajan, Purushothaman Sureshkumar and Mannathusamy Gopalakrishnan

Affiliation:

Keywords: green chemistry, microwave irradiation, dihydropyrimidinones, sulfated zirconia, Biginelli reaction

Abstract: Sulfated zirconia (ZrO2/SO4 2-) solid superacid has been proved to be an efficient reusable heterogeneous catalyst for three-component one-pot cyclocondensation reaction of β-dicarbonyl compounds and urea/thiourea with structurally diverse aromatic aldehydes in solvent-free conditions to furnish the corresponding 3,4-dihydropyrimidin-2(1H)-ones and -thiones in good to excellent yields both under microwave irradiation and thermal conditions.

Cite this article as:

Ezhilarasi R. Muthuvel, Govindaraju Ramalingam, Thanusu Jeyaraman, Kanagarajan Vijayakumar, Sureshkumar Purushothaman and Gopalakrishnan Mannathusamy, Microwave-Promoted Facile and Rapid Solvent-Free Synthesis Procedure for the Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Using ZrO2/SO42- as a Reusable Heterogeneous Catalyst, Letters in Organic Chemistry 2006; 3 (6) . https://dx.doi.org/10.2174/157017806777828493