Highlights in Organic Chemistry [Recent Advances in the Field of Peptide Nucleic Acids]

Nicola   M.   Howarth

doi:10.2174/157017806778341852

Abstract

Since their development, peptide nucleic acids (PNAs) have attracted much attention as potential pharmacological regulators of gene expression. Currently, applications of PNAs are restricted through deficiencies in target specificity, aqueous solubility and cellular uptake. This highlight reviews syntheses and hybridisation properties of recent PNA analogues designed to address these limitations.

Keywords: hybridisation properties, nucleobase modifications, side chain modifications, backbone modifications, PNA analogues, Peptide nucleic acids

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Letters in Organic Chemistry

Title: Highlights in Organic Chemistry [Recent Advances in the Field of Peptide Nucleic Acids]

Volume: 3 Issue: 7

Author(s): Nicola M. Howarth

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Keywords: hybridisation properties, nucleobase modifications, side chain modifications, backbone modifications, PNA analogues, Peptide nucleic acids

Abstract: Since their development, peptide nucleic acids (PNAs) have attracted much attention as potential pharmacological regulators of gene expression. Currently, applications of PNAs are restricted through deficiencies in target specificity, aqueous solubility and cellular uptake. This highlight reviews syntheses and hybridisation properties of recent PNA analogues designed to address these limitations.

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Howarth M. Nicola, Highlights in Organic Chemistry [Recent Advances in the Field of Peptide Nucleic Acids], Letters in Organic Chemistry 2006; 3 (7) . https://dx.doi.org/10.2174/157017806778341852