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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties

Author(s): Carlos S. Perez, Vivian Leliebre-Lara, Odette Concepcion, Francisco Coll, Daniel G. Rivera and Orlando Pando

Volume 3, Issue 7, 2006

Page: [519 - 522] Pages: 4

DOI: 10.2174/157017806778341870

Price: $65

Abstract

Four new spirostanes functionalized with the butyrolactone moiety were efficiently synthesized and submitted to preliminary biological tests. Two practical synthetic routes were designed to enable the incorporation of the γ-lactone functionality into rings A and B. Butyrolactones 5 and 10 showed a promising plant growth-promoting activity which renders them good candidates for further biological studies.

Keywords: butyrolactones, biological activity, steroidal sapogenins, Steroids


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