An Efficient Synthesis of 3-Benzyl-2H-Chromenes as Potential Antipicornavirus Agents

Nicoletta      Desideri

doi:10.2174/157017806778341915

Abstract

The 3-benzyl-2H-chromenes (3 a-d), designed as potential inhibitors of picornavirus infections, were synthesized by a simple and convenient three-step procedure starting from the O-alkylation of the appropriate 2-(hydroxymethyl)phenols with 1-bromo-3-phenylpropan-2-ones. The resulting ethers (1 a-d) were converted to the corresponding triphenylphosphonium bromides (2 a-d) and finally cyclized by an intramolecular Wittig reaction.

Keywords: 3-Benzyl-2H-chromenes, flavanoids, antipicornavirus agents

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Letters in Organic Chemistry

Title: An Efficient Synthesis of 3-Benzyl-2H-Chromenes as Potential Antipicornavirus Agents

Volume: 3 Issue: 7

Author(s): Nicoletta Desideri

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Keywords: 3-Benzyl-2H-chromenes, flavanoids, antipicornavirus agents

Abstract: The 3-benzyl-2H-chromenes (3 a-d), designed as potential inhibitors of picornavirus infections, were synthesized by a simple and convenient three-step procedure starting from the O-alkylation of the appropriate 2-(hydroxymethyl)phenols with 1-bromo-3-phenylpropan-2-ones. The resulting ethers (1 a-d) were converted to the corresponding triphenylphosphonium bromides (2 a-d) and finally cyclized by an intramolecular Wittig reaction.

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Desideri Nicoletta, An Efficient Synthesis of 3-Benzyl-2H-Chromenes as Potential Antipicornavirus Agents, Letters in Organic Chemistry 2006; 3 (7) . https://dx.doi.org/10.2174/157017806778341915