Novel Fibrinogen Receptor Antagonists - RGDF Mimetics, 4-(1,2,3,4- tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric Acid Derivatives

Title: Novel Fibrinogen Receptor Antagonists - RGDF Mimetics, 4-(1,2,3,4- tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric Acid Derivatives

Volume: 2 Issue: 3

Author(s): Sergei A. Andronati, Olga L. Malovichko, Andrei A. Krysko, Tatyana A. Kabanova, Tamara L. Karaseva and Anna S. Petrus

Affiliation:

Keywords: Fibrinogen receptor antagonists, αIIbβ3, GP IIb/IIIa, RGD mimetics, 1,2,3,4-tetrahydro-isoquinoline, platelet aggregation

Abstract: Two novel RGDF mimetics were synthesized with the use of 4-(1,2,3,4-tetrahydro-isoquinoline-7-yl)amino-4- oxo-butyric acid as a new surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to αIIbβ3 on washed human platelets.

Cite this article as:

Andronati A. Sergei, Malovichko L. Olga, Krysko A. Andrei, Kabanova A. Tatyana, Karaseva L. Tamara and Petrus S. Anna, Novel Fibrinogen Receptor Antagonists - RGDF Mimetics, 4-(1,2,3,4- tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric Acid Derivatives, Medicinal Chemistry 2006; 2 (3) . https://dx.doi.org/10.2174/157340606776930817