Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE

Title: Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE

Volume: 3 Issue: 2

Author(s): Pierre Renard, Daniel-Henri Caignard, Catherine Dacquet, Jean Boutin, Pascale Chomarat, Valerie Audinot-Bouchez, Rene Gree, Paul Mosset and Frederic Caijo

Affiliation:

Keywords: 8-HETE, benzofuran, PPARs

Abstract: The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.

Cite this article as:

Renard Pierre, Caignard Daniel-Henri, Dacquet Catherine, Boutin Jean, Chomarat Pascale, Audinot-Bouchez Valerie, Gree Rene, Mosset Paul and Caijo Frederic, Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8-HETE, Letters in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157017806775224332