K2CO3-Mediated Regioselective Synthesis of Isoxazoles and Pyrazolines

Mazaahir      Kidwai; Shuchi      Kukreja; Ruby      Thakur

doi:10.2174/157017806775224170

Abstract

3,5-Diarylisoxazoles and 1,3,5-triarylpyrazolines are synthesized via Michael addition of "hydroxylamine hydrochloride, phenylhydrazine" respectively over chalcones followed by cyclization using K2CO3 as solid support. Reactions are shown to be highly regioselective regardless of the nature of the substituent in the substrates and afforded single isoxazole and pyrazoline isomer in excellent yields.

Keywords: Michael addition, regioselectivity, chalcones, solid support

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Letters in Organic Chemistry

Title: K2CO3-Mediated Regioselective Synthesis of Isoxazoles and Pyrazolines

Volume: 3 Issue: 2

Author(s): Mazaahir Kidwai, Shuchi Kukreja and Ruby Thakur

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Keywords: Michael addition, regioselectivity, chalcones, solid support

Abstract: 3,5-Diarylisoxazoles and 1,3,5-triarylpyrazolines are synthesized via Michael addition of "hydroxylamine hydrochloride, phenylhydrazine" respectively over chalcones followed by cyclization using K2CO3 as solid support. Reactions are shown to be highly regioselective regardless of the nature of the substituent in the substrates and afforded single isoxazole and pyrazoline isomer in excellent yields.

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Kidwai Mazaahir, Kukreja Shuchi and Thakur Ruby, K2CO3-Mediated Regioselective Synthesis of Isoxazoles and Pyrazolines, Letters in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157017806775224170