KF/Al2O3 Mediated Aza-Michael Addition of Indoles to Electron-Deficient Olefins

Firouz   M.   Moghaddam; Ghasem   R.   Bardajee; Seyedeh   M. D.   Taimoory

doi:10.2174/157017806775224224

Abstract

KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as α,β-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.

Keywords: aza-Michael addition, KF/Al2O3, N-alkylation, Indole, Electron-deficient olefins

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: KF/Al2O3 Mediated Aza-Michael Addition of Indoles to Electron-Deficient Olefins

Volume: 3 Issue: 2

Author(s): Firouz M. Moghaddam, Ghasem R. Bardajee and Seyedeh M. D. Taimoory

Affiliation:

Keywords: aza-Michael addition, KF/Al2O3, N-alkylation, Indole, Electron-deficient olefins

Abstract: KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as α,β-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Moghaddam M. Firouz, Bardajee R. Ghasem and Taimoory M. D. Seyedeh, KF/Al2O3 Mediated Aza-Michael Addition of Indoles to Electron-Deficient Olefins, Letters in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157017806775224224