Current Status of Virtual Screening as Analysed by Target Class

Title: Current Status of Virtual Screening as Analysed by Target Class

Volume: 2 Issue: 1

Author(s): Martin J. Stoermer

Affiliation:

Keywords: Virtual screening, docking, kinase, GPCR, protease, receptors, review

Abstract: In silico virtual screening for drug discovery has become a hot topic in medicinal chemistry research during the last 5 years, growing from a largely academic pursuit concerned principally with validating the methods used, to a major early-stage technique for lead discovery in the pharmaceutical industry. In this review we highlight a few recent successes in ligand docking associated with virtual screening, paying particular attention to four major target classes of pharmaceutical interest (G Protein-Coupled receptors, nuclear hormone receptors, kinases, proteases). We also discuss some emerging trends in the field, some common limitations, and how they are being overcome.

Cite this article as:

Stoermer J. Martin, Current Status of Virtual Screening as Analysed by Target Class, Medicinal Chemistry 2006; 2 (1) . https://dx.doi.org/10.2174/157340606775197750