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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

[Complete 1,3-Asymmetric Induction into 3-Methyl-4-(3-Acetylpyrrol-1- yl)Butanal to 1-Acetyl-6-Methyl-8-Hydroxy-5,6,7,8-Tetrahydroindolizine Cyclization ]

Author(s): Giuliano Alagona, Raffaello Lazzaroni, Silvia Rocchiccioli and Roberta Settambolo

Volume 3, Issue 1, 2006

Page: [10 - 12] Pages: 3

DOI: 10.2174/157017806774964486

Price: $65

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Abstract

The formation of 1-acetyl-6-methyl-8-hydroxy-5,6,7,8-tetrahydroindolizine (3) from 3-methyl-4-(3- acetylpyrrol-1-yl)butanal (2), coming from the rhodium catalyzed hydroformylation of 2-methyl-3-(3- acetylpyrrol-1-yl)prop-1-ene (1), is reported. Evidences for both the complete diastereoselective cyclization of 2 and the configuration determination in 3 via 1H, 13 C and IR spectra are reported.

Keywords: pyrrolylbutanal, rhodium-catalyst, hydroxytetrahydroindolizines, hydroformylation, 1, 3-asymmetric induction


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