The Research of Conjunction Calculated Relationships Between Gold Nanoparticles and the Proteins

Qingquan      Guo; Juan      Yuan; Xiangzhu      He; Daguang      Li

doi:10.2174/157341312799362287

Abstract

Gold nanoparticles(GNPs) are very suitable for the drug carrier because of their intrinsic properties. Protein- or peptide- type drugs are popular at present with their high treatments. So the research of gold nanoparticles conjunction with proteins is attractive now. In this paper, the conjunction calculated relationships between gold nanoparticles and the protein are researched. Bull Serum Albumin (BSA) and Egg White Lysozyme (EWL) and two different sizes of gold nanoparticles are checked. The condition of conjunction is determined by spectrometry, followed by calculating the binding protein quantity of the surface of a gold nanoparticle and occupied area of a single protein. The results show that the quantity of bound protein in the surface of a gold nanoparticle increases with the particle size of gold nanoparticle; while more proteins are bound by gold nanoparticles when the molecular mass of protein is smaller.

Keywords: Gold nanoparticles, Protein, conjunction relationship, calculation, drug carrier, Bull Serum Albumin, Egg White Lysozyme, biocompatible