Abstract
In recent years, a large number of new potent symmetrical cytotoxic agents that act through different mechanisms have been described. Apoptosis induction is one of the most representative of these mechanisms. Recent articles have revealed that the activation of apoptosis pathways is the key mechanism by which cytotoxic tumor cells are killed. The present review highlights the importance of the molecular symmetry of several chemical structures and their relation with cytotoxic and apoptotic activity.
Keywords: Cancer, molecular symmetry, cytotoxicity, apoptosis
Mini-Reviews in Medicinal Chemistry
Title: Molecular Symmetry: A Structural Property Frequently Present in New Cytotoxic and Proapoptotic Drugs
Volume: 6 Issue: 6
Author(s): Carmen Sanmartín, Maria Font and Juan A. Palop
Affiliation:
Keywords: Cancer, molecular symmetry, cytotoxicity, apoptosis
Abstract: In recent years, a large number of new potent symmetrical cytotoxic agents that act through different mechanisms have been described. Apoptosis induction is one of the most representative of these mechanisms. Recent articles have revealed that the activation of apoptosis pathways is the key mechanism by which cytotoxic tumor cells are killed. The present review highlights the importance of the molecular symmetry of several chemical structures and their relation with cytotoxic and apoptotic activity.
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Cite this article as:
Sanmartín Carmen, Font Maria and Palop A. Juan, Molecular Symmetry: A Structural Property Frequently Present in New Cytotoxic and Proapoptotic Drugs, Mini-Reviews in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/138955706777435652
DOI https://dx.doi.org/10.2174/138955706777435652 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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