Present and Future of Recombinant Gonadotropins in Reproductive Medicine

Vincenzo      De Leo; Maria      Concetta Musacchio; Alessandra      Di Sabatino; Claudia      Tosti; Giuseppe      Morgante; Felice      Petraglia

doi:10.2174/138920112799361918

Abstract

Pharmacological ovarian stimulation has a major role in reproductive medicine and has been used in anovulatory patients and in the induction of multifollicular development required for the procedures of assisted reproductive techniques (ART). Currently, gonadotropins are the most important tools to proceed with ovarian stimulation for all purposes, including ART and anovulation disorders, like hypogonadotropic hypogonadism and hypothalamic hypophyseal dysfunction. Gonadotropin preparations derived from human urine have been used clinically since the early 1960s and the first urine-derived preparation containing only FSH (urofollitropin) became available in 1983. More recently, the application of recombinant DNA technology has resulted in the development of recombinant FSH produced in mammalian cells. In the last period, LH became available by recombinant DNA technology and is now a new option for protocols of ovarian stimulation. Treatment with gonadotropins has been shown to be effective in males affected by hypogonadotropic hypogonadism. This success has resulted in attempts to utilize FSH therapy in oligozoospermic men, aimed at obtaining a quantitative increase in sperm count. The purpose of this review was to examine the pharmacological aspects and different clinical applications of recombinant gonadotropins (FSH, LH, hCG) in the treatment of female infertility in all its aspects and their use also in the treatment of male infertility. This review will trace these events, from the past through to the present, and conclude with a glance towards the future.

Keywords: Recombinant gonadotropins, induction of ovulation, infertility, Gonadotropin preparations, anovulatory patients, ovarian stimulation, hypogonadotropic hypogonadism, oligozoospermic men, controlled ovarian hyperstimulation (COH), folliculogenesis, follicle stimulating hormone (FSH), luteal phase, follicular maturation, granulosa cells, oocyte maturation