The Roles of Corticotropin-Releasing Factor-Related Peptides and Their Receptors in the Cardiovascular System

Title: The Roles of Corticotropin-Releasing Factor-Related Peptides and Their Receptors in the Cardiovascular System

Volume: 7 Issue: 3

Author(s): Hossein P. Nazarloo, P. M. Buttrick, H. Saadat and A. J. Dunn

Affiliation:

Keywords: CRF, urocortin, cardiovascular, stress

Abstract: Corticotropin-releasing factor (CRF), CRF-related peptides and their receptors are present in the central nervous system and in peripheral tissues including the immune, reproductive and cardiovascular systems. CRF and urocortin (urocortin 1) bind to the CRF receptor type 1 (CRF1 receptor) and the CRF receptor type 2 (CRF2 receptor), whereas urocortin 2 (formerly known as stresscopin related peptide) and urocortin 3 (formerly known as stresscopin) bind with high affinity to the CRF2 receptor. Recent studies show that urocortin 1, urocortin 2 and urocortin 3 are potent regulators of cardiovascular function. This review highlights the role of cardiovascular CRF and related peptides and its relevance in mediating the adaptive response of the cardiovascular system to stressful conditions.

Cite this article as:

Nazarloo P. Hossein, Buttrick M. P., Saadat H. and Dunn J. A., The Roles of Corticotropin-Releasing Factor-Related Peptides and Their Receptors in the Cardiovascular System, Current Protein & Peptide Science 2006; 7 (3) . https://dx.doi.org/10.2174/138920306777452358

DOI https://dx.doi.org/10.2174/138920306777452358	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550