Abstract
This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin
Current Pharmaceutical Design
Title: Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery
Volume: 17 Issue: 38
Author(s): Adam Lesner, Anna Legowska, Magdalena Wysocka and Krzysztof Rolka
Affiliation:
Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin
Abstract: This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
Export Options
About this article
Cite this article as:
Lesner Adam, Legowska Anna, Wysocka Magdalena and Rolka Krzysztof, Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery, Current Pharmaceutical Design 2011; 17 (38) . https://dx.doi.org/10.2174/138161211798999393
DOI https://dx.doi.org/10.2174/138161211798999393 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Therapeutic Potential for Thyroid Hormone Receptor-β Selective Agonists for Treating Obesity, Hyperlipidemia and Diabetes
Current Vascular Pharmacology Differentiation Between Osteoporotic and Neoplastic Vertebral Fractures: State of The Art and Future Perspectives
Current Medical Imaging Oxidized Polysaccharides as Green and Sustainable Biomaterials
Current Organic Chemistry Therapeutic Benefits of <i>Piper nigrum</i>: A Review
Current Bioactive Compounds Antimicrobial Activity of Willowherb (Epilobium angustifolium L.) Leaves and Flowers
Current Drug Targets Artificial Organs: A New Option for Treating Osteoarthritis
Current Drug Delivery Interactions Between Cholinergic and Fibroblast Growth Factor Receptors in Brain Trophism and Plasticity
Current Protein & Peptide Science Inhibiting Cyclin-Dependent Kinase / Cyclin Activity for the Treatment of Cancer and Cardiovascular Disease
Current Pharmaceutical Biotechnology 5-Hydroxymethylfurfural (HMF) in Organic Synthesis: A Review of its Recent Applications Towards Fine Chemicals
Current Organic Synthesis Pharmaceutical Nanotechnology United States Patent Watch (April – June 2015)
Pharmaceutical Nanotechnology Surgical Treatment of Endometriosis
Current Women`s Health Reviews Deubiquitinating Enzyme Inhibitors and their Potential in Cancer Therapy
Current Cancer Drug Targets Lesson Learned from Nature for the Development of Novel Anti-Cancer Agents: Implication of Isoflavone, Curcumin, and their Synthetic Analogs
Current Pharmaceutical Design RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy
Current Topics in Medicinal Chemistry Targeting Aurora Kinases in Cancer Treatment
Current Drug Targets Selenium and Colon Cancer – From Chemoprevention to New Treatment Modality
Anti-Cancer Agents in Medicinal Chemistry New Targets for the Modulation of Radiation Response - Selective Inhibition of the Enzyme Cyclooxygenase 2
Current Medicinal Chemistry - Anti-Cancer Agents State of Research Tracks and Property Protection of Photodynamic Sensitizers and Delivery Methodologies
Recent Patents on Chemical Engineering Application of Proteomics to the Discovery of Cancer Biomarkers
Current Cancer Therapy Reviews Lipid Based Nanosystems for Curcumin: Past, Present and Future
Current Pharmaceutical Design