Abstract
Reactive oxygen and nitrogen species play complex roles in the physiological regulation of cell metabolism and in many disease processes as well, including viral infections. Viral replication occurs within living cells and is totally dependent on its hosts biosynthetic machinery. Many intracellular signaling pathways exploited by viruses for their own replication are regulated by the oxidoreductive (redox) state of the host cell. Consequently, factors that alter the balance between reactive oxygen/nitrogen species and antioxidant molecules/enzymes-including metabolic conditions like malnutrition, obesity, and diabetes-can influence cells susceptibility to viral infection, the efficiency of viral replication, and as a result the progression and severity of virus-induced diseases. This review examines the ways in which the host-cell redox state affect viral replication and the actual potential of antioxidants to combat viral infections.
Keywords: Redox state, metabolism, viral infection, antioxidants, oxidative stress, apoptosis, proinflammatory cytokines, autophagosomes, diabetes mellitus, obesity
Current Pharmaceutical Design
Title: Intracellular Redox Signaling as Therapeutic Target for Novel Antiviral Strategy
Volume: 17 Issue: 35
Author(s): Lucia Nencioni, Rossella Sgarbanti, Donatella Amatore, Paola Checconi, Ignacio Celestino, Dolores Limongi, Simona Anticoli, Anna Teresa Palamara and Enrico Garaci
Affiliation:
Keywords: Redox state, metabolism, viral infection, antioxidants, oxidative stress, apoptosis, proinflammatory cytokines, autophagosomes, diabetes mellitus, obesity
Abstract: Reactive oxygen and nitrogen species play complex roles in the physiological regulation of cell metabolism and in many disease processes as well, including viral infections. Viral replication occurs within living cells and is totally dependent on its hosts biosynthetic machinery. Many intracellular signaling pathways exploited by viruses for their own replication are regulated by the oxidoreductive (redox) state of the host cell. Consequently, factors that alter the balance between reactive oxygen/nitrogen species and antioxidant molecules/enzymes-including metabolic conditions like malnutrition, obesity, and diabetes-can influence cells susceptibility to viral infection, the efficiency of viral replication, and as a result the progression and severity of virus-induced diseases. This review examines the ways in which the host-cell redox state affect viral replication and the actual potential of antioxidants to combat viral infections.
Export Options
About this article
Cite this article as:
Nencioni Lucia, Sgarbanti Rossella, Amatore Donatella, Checconi Paola, Celestino Ignacio, Limongi Dolores, Anticoli Simona, Teresa Palamara Anna and Garaci Enrico, Intracellular Redox Signaling as Therapeutic Target for Novel Antiviral Strategy, Current Pharmaceutical Design 2011; 17 (35) . https://dx.doi.org/10.2174/138161211798357728
DOI https://dx.doi.org/10.2174/138161211798357728 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Rheumatoid Arthritis: An Autoimmune Disease with Female Preponderance and Cardiovascular Risk Equivalent to Diabetes Mellitus: Role of Cardiovascular Magnetic Resonance
Inflammation & Allergy - Drug Targets (Discontinued) Role of Advanced Glycation End Products (AGEs) and Oxidative Stress in Diabetic Retinopathy
Current Pharmaceutical Design The Effect of Antihypertensive Drugs on Central Blood Pressure Beyond Peripheral Blood Pressure. Part I: (Patho)-Physiology, Rationale and Perspective on Pulse Pressure Amplification
Current Pharmaceutical Design Vascular Factors and Mitochondrial Dysfunction: a Central Role in the Pathogenesis of Alzheimer’s Disease
Current Neurovascular Research Inducers of Heme Oxygenase-1
Current Pharmaceutical Design Pharmacological Neuroprotection in Stroke: Rationale, State-of-the-art and Future Directions
Current Neuropharmacology Pleiotropic Actions of PPARg Activators Thiazolidinediones in Cardiovascular Diseases
Current Pharmaceutical Design Anti-Platelet Treatment of Middle-Sized Abdominal Aortic Aneurysms
Current Vascular Pharmacology Tartaric Acid Enhances Adrenergic Receptor Activity: Test of a General Theory of Extracellular Aminergic GPCR Enhancer Discovery
Current Drug Discovery Technologies Methylglyoxal and Advanced Glycation Endproducts: New Therapeutic Horizons?
Recent Patents on Cardiovascular Drug Discovery Anderson-Fabry Disease: A Multiorgan Disease
Current Pharmaceutical Design Inflammation, High Density Lipoprotein and Endothelium
Current Medicinal Chemistry Aptamers as Therapeutics in Cardiovascular Diseases
Current Medicinal Chemistry Meet Our Associate Editor:
Cardiovascular & Hematological Disorders-Drug Targets Therapeutic Angiogenesis for Peripheral Artery Diseases by Autologous Bone Marrow Cell Transplantation
Current Pharmaceutical Design Mesenchymal Cells in the Treatment of Spinal Cord Injury: Current & Future Perspectives
Current Stem Cell Research & Therapy High-Resolution CT Imaging Findings of Collagen Vascular Disease- Associated Interstitial Lung Disease
Current Respiratory Medicine Reviews Targeting Conserved Pathways: Mitochondrial Dysfunction and Beyond
Current Neurovascular Research Anti-inflammatory and Hypolipidemic Effect of Novel Conjugates with Trolox and Other Antioxidant Acids
Medicinal Chemistry Molecular Mechanisms of the Antiatherogenic Action of Adiponectin
Vascular Disease Prevention (Discontinued)