The Boron Imprint into Combined Catalytic Organic Reactions

Amadeu      Bonet; Henrik      Gulyas; Elena      Fernandez

doi:10.2174/138527211798072421

Abstract

Combined reactions through organoboron intermediates belong to the class of sequential reactions whereby the advantages are clear in terms of efficiency and selectivity. The goal to prepare target molecules from simple substrates requires strategic steps and very selective formation of new bonds. The addition of boryl units to unsaturated substrates can be performed chemo-, regio- and stereoselectively, therefore the organoboron intermediates might be easily transformed into the functionalized molecules, with total retention of configuration. Taking advantage of these protocols, here we describe the most recent advances in combined reactions through B chemistry.

Keywords: Cross-coupling, bis(pinacolato)diboron, bis(catecholato)diboron, boration, dimerization, cyclization, Organic Reactions, organic synthesis, building blocks, organoboronic esters, reductive elimination, oxidative addition, Transition metal-catalyzed, atom-economical manner, crystalline materials