Abstract
During the past decades, we have witnessed significant advances in our understanding of the molecular etiology of Parkinsons disease (PD). The unearthing of the causative genes for hereditary PD accelerated not only the studies of the molecular mechanisms underlying this pathology, but also set mitochondria at the center of PD pathology. In this review we revisit mitochondrial key role and propose a hypothesis for PD, that allows the unification of both sporadic and familial PD forms. In light of this we also discuss new promising disease-modified therapies.
Keywords: Mitochondria, mitochondrial DNA, mitochondrial biogenesis, protein oligomerization, intracellular traffic, autophagy, oxidative stress, lysosomal function, Parkinson's Disease, missense mutations
Current Pharmaceutical Design
Title: The Mitochondrial Cascade Hypothesis for Parkinsons Disease
Volume: 17 Issue: 31
Author(s): Sandra M. Cardoso
Affiliation:
Keywords: Mitochondria, mitochondrial DNA, mitochondrial biogenesis, protein oligomerization, intracellular traffic, autophagy, oxidative stress, lysosomal function, Parkinson's Disease, missense mutations
Abstract: During the past decades, we have witnessed significant advances in our understanding of the molecular etiology of Parkinsons disease (PD). The unearthing of the causative genes for hereditary PD accelerated not only the studies of the molecular mechanisms underlying this pathology, but also set mitochondria at the center of PD pathology. In this review we revisit mitochondrial key role and propose a hypothesis for PD, that allows the unification of both sporadic and familial PD forms. In light of this we also discuss new promising disease-modified therapies.
Export Options
About this article
Cite this article as:
M. Cardoso Sandra, The Mitochondrial Cascade Hypothesis for Parkinsons Disease, Current Pharmaceutical Design 2011; 17 (31) . https://dx.doi.org/10.2174/138161211798072508
DOI https://dx.doi.org/10.2174/138161211798072508 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The HGF-Met Signaling Axis: Emerging Themes and Targets of Inhibition
Current Protein & Peptide Science Central Nervous System Depressants and Risk of Hospitalization due to Community-Acquired Pneumonia in very Old Patients
Current Drug Safety Peptide Immunotherapies in Type 1 Diabetes: Lessons from Animal Models
Current Medicinal Chemistry Antiviral Drugs that Target Cellular Proteins May Play Major Roles in Combating HIV Resistance
Current Pharmaceutical Design Central Nervous System-Related
Current Bioactive Compounds Lower K<sub>V</sub>7.5 Potassium Channel Subunit Expression in an Animal Model of Paroxysmal Dystonia
CNS & Neurological Disorders - Drug Targets SIST-M-IR Activities of Daily Living Items that Best Discriminate Clinically Normal Elderly from those with Mild Cognitive Impairment
Current Alzheimer Research The Promise of Slow Down Ageing May Come from Curcumin
Current Pharmaceutical Design The Importance of Selenium Biofortification in Food Crops
Current Nutrition & Food Science Induction of Oral Tolerance with Transgenic Plants Expressing Antigens for Prevention/Treatment of Autoimmune, Allergic and Inflammatory Diseases
Current Pharmaceutical Biotechnology Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress
CNS & Neurological Disorders - Drug Targets Environment, Physical Activity, and Neurogenesis: Implications for Prevention and Treatment of Alzhemiers Disease
Current Alzheimer Research Hypoxia Inducible Factor-1α, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis
Current Drug Targets 5-Lipoxygenase: A Promising Drug Target Against Inflammatory Diseases-Biochemical and Pharmacological Regulation
Current Drug Targets The Current Status of Sweat Testing For Drugs of Abuse: A Review
Current Medicinal Chemistry Neurokinin 3 (NK3) Receptor Modulators for the Treatment of Psychiatric Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Practical Issues in Stem Cell Therapy for Alzheimers Disease
Current Alzheimer Research Gene Expression Suggests Spontaneously Hypertensive Rats May Have Altered Metabolism and Reduced Hypoxic Tolerance
Current Neurovascular Research Brain-to-Plasma Distribution Ratio of the Biflavone Amentoflavone in the Mouse
Drug Metabolism Letters DHA–lysophospholipid Production
Current Organic Chemistry