The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing

Title: The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing

Volume: 17 Issue: 30

Author(s): Y. Cui and P. Madeddu

Affiliation:

Keywords: Stem cells, cardiovascular disease, ischemia, homing, signalling, repair, endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), chemokine, proteases

Abstract: Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.

Cite this article as:

Cui Y. and Madeddu P., The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing, Current Pharmaceutical Design 2011; 17 (30) . https://dx.doi.org/10.2174/138161211797904109