Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Endothelial Progenitor Cells: Quod Erat Demonstrandum?

Author(s): Dirk Strunk

Volume 17, Issue 30, 2011

Page: [3245 - 3251] Pages: 7

DOI: 10.2174/138161211797904127

Price: $65

Abstract

A constantly growing body of research has been performed mainly over the past decade and a half, aiming to facilitate our still limited understanding of the biology and function of various different cell types which collectively have been termed endothelial progenitor cells. This review intends to critically outline aspects of terminology, origin and applicability of the somatic progenitors which are thought to maintain integrity and support regeneration of the inner lining of vessels through proliferation. Despite reasonable progress in the field, we are still not confident regarding the precise phenotype and function of endothelial progenitor cells. Model systems that have been developed to study the vascular regenerative potential of human endothelial progenitor cells in animal models in vivo present principle tools for testing new agents that modulate vascular homeostasis and regeneration.

Keywords: EPC, ECFC, EC, endothelial cells, stem cells, progenitor cells, transplantation, vascular homeostasis, myeloid cells, mesenchymal stromal/stem cells


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy