Protein-Peptide Interaction Studies Demonstrate the Versatility of Calmodulin Target Protein Binding

Title: Protein-Peptide Interaction Studies Demonstrate the Versatility of Calmodulin Target Protein Binding

Volume: 13 Issue: 5

Author(s): Hiroaki Ishida and Hans J. Vogel

Affiliation:

Keywords: Calcium, calmodulin, calmodulin-binding peptide, target-protein, calmodulin-target complex, myristoylation

Abstract: Calmodulin (CaM) is a prototypical Ca2+-sensor protein that can control many important biological functions by binding to hundreds of target proteins. To gain insight into the versatility of CaM-target recognition, we have analyzed the complex structures for many types of CaM-binding peptides and some target proteins. In particular, some recently reported novel complex structures reveal that the versatile target binding of CaM is accommodated by its flexible domain arrangement and the malleability of its interfaces.

Cite this article as:

Ishida Hiroaki and Vogel J. Hans, Protein-Peptide Interaction Studies Demonstrate the Versatility of Calmodulin Target Protein Binding, Protein & Peptide Letters 2006; 13 (5) . https://dx.doi.org/10.2174/092986606776819600

DOI https://dx.doi.org/10.2174/092986606776819600	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305