Abstract
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disease that involves menstrual dysfunction and reproductive difficulty as well as metabolic problems. From a genetic point of view, it is a complex disease that is subject to environmental influences, mainly dietary, which makes it similar to other metabolic processes, such as diabetes and obesity. So, the interest of the diagnosis of the PCOS is, not only to improve fertility but to prevent possible future medical complications like the diabetes mellitus and the obesity.
Due to the classical definition of PCOS as functional hyperandrogenism, the race to discover genetic alterations that could lead to the development of PCOS started with the androgen metabolism genes. However, the list of candidates was later expanded to other genes outside this hormonal pathway, and it now includes genes involved in carbohydrate and lipid metabolism as well as those involved in inflammatory processes.
Synopsis: The list of genes candidates involved in PCOS is related to diabetes and inflammatory processes.
Keywords: Polymorphism, Polycystic ovary syndrome, Insulin resistance, Diabetes Mellitus, obesity, hyperandrogenism, trauma, haemorrhage, Hyperinsulinism, GWAs
Current Diabetes Reviews
Title: Common Genetic Aspects Between Polycystic Ovary Syndrome and Diabetes Mellitus
Volume: 7 Issue: 6
Author(s): Nicolas Mendoza
Affiliation:
Keywords: Polymorphism, Polycystic ovary syndrome, Insulin resistance, Diabetes Mellitus, obesity, hyperandrogenism, trauma, haemorrhage, Hyperinsulinism, GWAs
Abstract: Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disease that involves menstrual dysfunction and reproductive difficulty as well as metabolic problems. From a genetic point of view, it is a complex disease that is subject to environmental influences, mainly dietary, which makes it similar to other metabolic processes, such as diabetes and obesity. So, the interest of the diagnosis of the PCOS is, not only to improve fertility but to prevent possible future medical complications like the diabetes mellitus and the obesity.
Due to the classical definition of PCOS as functional hyperandrogenism, the race to discover genetic alterations that could lead to the development of PCOS started with the androgen metabolism genes. However, the list of candidates was later expanded to other genes outside this hormonal pathway, and it now includes genes involved in carbohydrate and lipid metabolism as well as those involved in inflammatory processes.
Synopsis: The list of genes candidates involved in PCOS is related to diabetes and inflammatory processes.
Export Options
About this article
Cite this article as:
Mendoza Nicolas, Common Genetic Aspects Between Polycystic Ovary Syndrome and Diabetes Mellitus, Current Diabetes Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339911797579142
DOI https://dx.doi.org/10.2174/157339911797579142 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Validated RP-HPLC Method for Simultaneous Estimation of Valsartan & Gliclazide in Bulk and Dosage Forms
Current Pharmaceutical Analysis Recent Development of Anticancer Therapeutics Targeting Akt
Recent Patents on Anti-Cancer Drug Discovery The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Exploring N<sup>1</sup>-p-Fluorobenzyl-Cymserine as an Inhibitor of 5-Lipoxygenase as a Candidate for Type 2 Diabetes and Neurodegenerative Disorder Treatment
CNS & Neurological Disorders - Drug Targets The Relationship Between Inflammation, Platelet Activation and Antiplatelet Resistance
Inflammation & Allergy - Drug Targets (Discontinued) Cerebrovascular Complications of Diabetes: Focus on Stroke
Endocrine, Metabolic & Immune Disorders - Drug Targets Therapy Based on the Regulation of Thiol-dependent Redox Systems
Current Medicinal Chemistry The Role of Peroxidation of Mitochondrial Membrane Phospholipids in Pancreatic β -Cell Failure
Current Diabetes Reviews Pathogenicity of the 1918 Pandemic Influenza Virus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry BeMORE: A Novel Method for Detection of Adverse Fetal Effects Induced by Drugs
Current Drug Safety Protein Interactions Between the C-Terminus of Aβ-Peptide and Phospholipase A<sub>2</sub> - A Structure Biology Based Approach to Identify Novel Alzheimer's Therapeutics
CNS & Neurological Disorders - Drug Targets Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview
Mini-Reviews in Medicinal Chemistry New Pharmacologic Approaches to Prevent Thromboembolism in Patients with Atrial Fibrillation
Current Vascular Pharmacology Hypothalamic AMP-activated Protein Kinase as a Regulator of Food Intake and Energy Balance
CNS & Neurological Disorders - Drug Targets A Comprehensive Review on the Biological and Pharmacological Activities of Rhodanine Based Compounds for Research and Development of Drugs
Mini-Reviews in Medicinal Chemistry Recent Advances in Nanotechnology-Based Drug Delivery Approaches for Alzheimer disease
Current Drug Targets Direct Interaction of Dietary Lipids Carried in Chylomicron Remnants with Cells of the Artery Wall: Implications for Atherosclerosis Development
Current Pharmaceutical Design Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic Pain
Current Drug Targets - CNS & Neurological Disorders Urtica dioica Extract Inhibits Cell Proliferation and Induces Apoptosis in HepG2 and HTC116 as Gastrointestinal Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry An Overview of Debenzylation Methods to Obtain 1-Deoxynojirimycin (DNJ)
Mini-Reviews in Organic Chemistry