Voltammetric Stripping Methods for Direct Determination of Disopyramide

Title: Voltammetric Stripping Methods for Direct Determination of Disopyramide

Volume: 8 Issue: 1

Author(s): Muharrem Duran, Zehra Durmus, Ibrahim H. Tasdemir and Esma Kilic

Affiliation:

Keywords: Disopyramide, Electrochemical behavior, Voltammetric stripping methods, Assay, Glassy carbon electrode, Limit of detection, Limit of quantitation, Pharmaceutical preparations, Biological samples, Validation parameters

Abstract: Electrochemical behavior of disopyramide (DPA) on glassy carbon electrode (GCE) was investigated by using cyclic voltammetry, square-wave voltammetry and constant potential bulk electrolysis. Adsorption and diffusion properties of DPA were evaluated. Differential pulse anodic adsorptive stripping voltammetric (DPAAdSV) and squarewave anodic adsorptive stripping voltammetric (SWAAdSV) methods were developed for its direct determination in pharmaceutical preparations and biological samples. Linear working concentration range for both methods was found as 3x10-7 M (0.102 mg/L) - 3x10-6 M (1.0 mg/L). Limit of detection and limit of quantitation for DPAAdSV were found to be 2.9x10-7 M (0.10 mg/L) and 9.5x10-7 M (0.32 mg/L), respectively and they were calculated to be 1.4x10-7 M (0.05 mg/L) and 4.5x10-7 M (0.15 mg/L) for SWAAdSV. Proposed methods were successfully applied to determine the content of DPA in pharmaceutical preparations and biological samples.

Cite this article as:

Duran Muharrem, Durmus Zehra, H. Tasdemir Ibrahim and Kilic Esma, Voltammetric Stripping Methods for Direct Determination of Disopyramide, Current Pharmaceutical Analysis 2012; 8 (1) . https://dx.doi.org/10.2174/157341212798995584