Abstract
P2X7 is an ATP-gated non-selective cation channel expressed primarily on cells of hematopoietic origin, such as macrophages and microglia. Since the initial cloning of this channel, enormous progress has been made in the understanding of the physiology, pharmacology and therapeutic utility of P2X7. This article attempts to review the biology of P2X7 with a focus on the complex pharmacology of this channel. Finally, the authors discuss the role of P2X7 as an analgesic drug target and raise some of the challenges and issues that face the P2X7 research community.
Keywords: P2X7, pain, IL-1β, inflammation, purinergic, ATP-gated non-selective cation channel, hematopoietic origin, macrophages, microglia, therapeutic utility of P2X7, Analgesic Drug Target, ATP gated ion channels, nonselective flux, currentvoltage relationship, P2X7 ACTIVATION AND MATURE IL-1 RELEASE
Current Pharmaceutical Biotechnology
Title: The Physiology, Pharmacology and Future of P2X7 as An Analgesic Drug Target: Hype or Promise?
Volume: 12 Issue: 10
Author(s): Anindya Bhattacharya, Robert A. Neff and Alan D. Wickenden
Affiliation:
Keywords: P2X7, pain, IL-1β, inflammation, purinergic, ATP-gated non-selective cation channel, hematopoietic origin, macrophages, microglia, therapeutic utility of P2X7, Analgesic Drug Target, ATP gated ion channels, nonselective flux, currentvoltage relationship, P2X7 ACTIVATION AND MATURE IL-1 RELEASE
Abstract: P2X7 is an ATP-gated non-selective cation channel expressed primarily on cells of hematopoietic origin, such as macrophages and microglia. Since the initial cloning of this channel, enormous progress has been made in the understanding of the physiology, pharmacology and therapeutic utility of P2X7. This article attempts to review the biology of P2X7 with a focus on the complex pharmacology of this channel. Finally, the authors discuss the role of P2X7 as an analgesic drug target and raise some of the challenges and issues that face the P2X7 research community.
Export Options
About this article
Cite this article as:
Bhattacharya Anindya, A. Neff Robert and D. Wickenden Alan, The Physiology, Pharmacology and Future of P2X7 as An Analgesic Drug Target: Hype or Promise?, Current Pharmaceutical Biotechnology 2011; 12 (10) . https://dx.doi.org/10.2174/138920111798357429
DOI https://dx.doi.org/10.2174/138920111798357429 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cardiopulmonary Interactions in Children with Heart Failure
Current Cardiology Reviews High-Density Lipoprotein: Key Molecule in Cholesterol Efflux and the Prevention of Atherosclerosis
Current Pharmaceutical Design Immunopathology of Brucella Infection
Recent Patents on Anti-Infective Drug Discovery Molecular and Cellular Activities of Vitamin E Analogues
Mini-Reviews in Medicinal Chemistry CT Virtual Intravascular Endoscopy in the Visualization of Coronary Plaques: A Pictorial Essay
Current Medical Imaging Novel Therapeutic Strategies Targeting Vascular Redox in Human Atherosclerosis
Recent Patents on Cardiovascular Drug Discovery Supercritical Fluid Processing of Materials for Regenerative Medicine
Recent Patents on Regenerative Medicine Fragile X Mental Retardation Protein: Past, Present and Future
Current Protein & Peptide Science The Hemostasis System in Murine Atherosclerosis
Current Drug Targets Neuropilin Signalling in Vascular Development and Pathology
Current Angiogenesis (Discontinued) A PHACES Syndrome Unmasked by Propranolol Interruption in a Tetralogy of Fallot Patient: Case Report and Extensive Review on New Indications of Beta Blockers
Current Medicinal Chemistry Perspectives on Medicinal Properties of Benzoquinone Compounds
Mini-Reviews in Medicinal Chemistry Recent Advances in the Discovery and Development of Marine Natural Products with Cardiovascular Pharmacological Effects
Mini-Reviews in Medicinal Chemistry Spontaneous Coronary Artery Dissection: Does Being Unemployed Matter? Insights from the GSCAD Registry
Current Cardiology Reviews Phytosterols: Perspectives in Human Nutrition and Clinical Therapy
Current Medicinal Chemistry Echocardiographic Hemodynamic Monitoring in the Critically Ill Patient
Current Cardiology Reviews Prevention of Macrovascular Disease in Type 2 Diabetic Patients: Blockade of the Renin-Angiotensin-Aldosterone System
Current Diabetes Reviews Plant Sterols and Stanols in the Treatment of Dyslipidemia: New Insights into Targets and Mechanisms Related to Cardiovascular Risk
Current Pharmaceutical Design Editorial (Thematic Issue: Frontiers in Atherosclerosis, Heart Disease and Diabetes)
Cardiovascular & Hematological Disorders-Drug Targets Nonbacterial Thrombotic Endocarditis (Marantic Endocarditis) in Cancer Patients
Cardiovascular & Hematological Disorders-Drug Targets