Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors

Title: Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors

Volume: 3 Issue: 4

Author(s): Stefano Moro, Flavia Varano, Giorgio Cozza, Mario A. Pagano, Giuseppe Zagotto, Adriana Chilin, Adriano Guiotto, Daniela Catarzi, Vittoria Calotta and Lorenzo A. Pinna

Affiliation:

Keywords: Kinase CK2, CK2 inhibitors, virtual screening

Abstract: Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Using a combined virtual screening approach, we have identified the pyrazoloquinazoline tricyclic system as a novel scaffold to design new kinase CK2 inhibitors.

Cite this article as:

Moro Stefano, Varano Flavia, Cozza Giorgio, Pagano A. Mario, Zagotto Giuseppe, Chilin Adriana, Guiotto Adriano, Catarzi Daniela, Calotta Vittoria and Pinna A. Lorenzo, Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors, Letters in Drug Design & Discovery 2006; 3 (4) . https://dx.doi.org/10.2174/157018006776743233