Abstract
Recent advances in Pd-catalysed cross-couplings have exploited subtle changes (ligands, additives, reagent choice) that can influence both catalyst activity, selectivity and longevity. In the last few decades it has been noted that the addition of alkenes (olefins) as ligands for Pd can have a dramatic effect on these reactions. More recently, chemists have focussed on designing alkene-containing ligands to take advantage of their benefits. This review summarises the fundamentals of alkene ligands in Pd-catalysed cross-couplings. The development of alkene and mixed ‘hemilabile’ phosphine-alkene ligands is further highlighted.
Keywords: Palladium, Cross-coupling, Alkenes, Catalysis, C-X Activation, Ligand effects, AUXILIARY LIGANDS, HETEROBIDENTATE LIGANDS, platinum complex, Zero-valent complexes, Reductive Elimination, POLYDENTATE ALKENE LIGANDS, 1H NMR spectroscopy, Pd-catalysed reactions
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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