Cancer Targeted Metallic Nanoparticle: Targeting Overview, Recent Advancement and Toxicity Concern

Sohail      Akhter; Mohammad      Zaki Ahmad; Anjali      Singh; Iqbal      Ahmad; Mahfoozur      Rahman; Mohammad      Anwar; Gaurav      Kumar Jain; Farhan      Jalees Ahmad; Roop      Krishen Khar

doi:10.2174/138161211796391001

Abstract

The targeted delivery of theranostic agents to the cancer cells is one of the major challenges and an active field of research in the development of cancer chemotherapeutic approaches. Theranostic metallic nanoparticles (TMNPs) have garnered increasing attention in recent years as a novel tool for theranostic application such as imaging, diagnosis, and therapeutic delivery of active agents to tumour specific cells. This paper attempts to unveil the multidimensional theranostic aspects of multifunctional metallic nanoparticles (MNPs) including passive and active targeting (HER2, Folate, Angiogenesis etc.) as well as the RES escaping approach. Special attention is given to the theranostic application of MNPs in oncology. Patents issued by the US office in this nanotechnological arena are also included emphasising the importance of MNPs in current cancer treatment/imaging research scenario. Keeping in mind the blooming research in clinical application directed nanotechnology; toxicity concerns related with MNPs are. also discussed, in element.

Keywords: Metallic nanoparticles (MNPs), Active and passive targeting, Patents, Theranostic application, Quantum dots, Toxicity assessment, Toxicity, Metallic nanoparticles, Abraxan, Doxil, tumours, electrostatic, diagnostic, theranostic, oncological, mononuclear, phagocyte, zeta potential