Abstract
Pyrazolo[1,5-a]pyridines have become subject to growing interest by both synthetic and medicinal chemists, and as such new and simple methods for their synthesis are becoming increasingly more important. They exhibit reactivity which permits substitution at various positions, allowing many diverse chemical structures to be made. This review briefly discusses the medicinal uses of pyrazolo[1,5-a]pyridines, it outlines the synthetic methods which have been used to make them and discusses the chemistries which have been carried out to further functionalise the ring system.
Keywords: pyrazolo[1,5-a]pyridine, SYNTHESIS, Pyrazole Ring Formation, Carbon-Nitrogen Bond Formation, Nitrogen-Nitrogen Bond Formation, Carbon-Carbon Bond Formation, Pyridine Ring Formation, Halogenation, Alkylation, Nitrosation, Nitration, Nucleophilic Substitution, Deprotonation, Palladium-Catalysed Reactions, quinolines
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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