Abstract
Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in the late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if too broad an effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.
Keywords: Topiramate, addictions, treatment, drug abuse, dysfunctional, hedonic, ritualized, amphetamines, morphine, naltrexone, mesolimbic, synaptic, neuroanatomical, vaccines, ethanol, sensitization, kainate
Current Pharmaceutical Design
Title: The Potential Interest of Topiramate in Addictions
Volume: 17 Issue: 14
Author(s): Gabriel Thorens, Joel Billieux, Rita Manghi, Riaz Khan, Yasser Khazaal and Daniele Fabio Zullino
Affiliation:
Keywords: Topiramate, addictions, treatment, drug abuse, dysfunctional, hedonic, ritualized, amphetamines, morphine, naltrexone, mesolimbic, synaptic, neuroanatomical, vaccines, ethanol, sensitization, kainate
Abstract: Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in the late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if too broad an effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.
Export Options
About this article
Cite this article as:
Thorens Gabriel, Billieux Joel, Manghi Rita, Khan Riaz, Khazaal Yasser and Fabio Zullino Daniele, The Potential Interest of Topiramate in Addictions, Current Pharmaceutical Design 2011; 17 (14) . https://dx.doi.org/10.2174/138161211796150864
DOI https://dx.doi.org/10.2174/138161211796150864 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Farnesyltransferase Inhibitors: Overview of their Action and Role in Solid Malignancy Therapy
Letters in Drug Design & Discovery Expression and Function of Anti-Inflammatory Interleukins: The Other Side of the Vascular Response to Injury
Current Vascular Pharmacology Choline Transporter CHT Regulation and Function in Cholinergic Neurons
Central Nervous System Agents in Medicinal Chemistry GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma
Current Drug Targets Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery
Current Topics in Medicinal Chemistry Th17 Cells in Airway Diseases
Current Molecular Medicine The Innate Immunity in Alzheimer Disease- Relevance to Pathogenesis and Therapy
Current Pharmaceutical Design Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease
Current Alzheimer Research Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in Control of Autonomic and Neuroendocrine Functions: A Review
Current Neuropharmacology Mechanical Methods for Dry Particle Coating Processes and Their Applications in Drug Delivery and Development
Recent Patents on Drug Delivery & Formulation Serotonin Receptors, Type 4: A New Hope?
Current Drug Targets Longitudinal Analysis of Adherence to First-Line Antiretroviral Therapy: Evidence of Treatment Sustainability from an Indian HIV Cohort
Current HIV Research Neurodevelopmental Delay and Intellectual Disability in Pediatric Heart Transplant
Current Psychiatry Reviews Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Alzheimers and Dementia in the Oldest-Old: A Century of Challenges
Current Alzheimer Research The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness
Current Drug Targets Disease-Related Changes in TRPV1 Expression and Its Implications for Drug Development
Current Topics in Medicinal Chemistry Autonomic Nervous System Alterations in Rett Syndrome
Current Pediatric Reviews Electromagnetic Field in Alzheimer’s Disease: A Literature Review of Recent Preclinical and Clinical Studies
Current Alzheimer Research Word Forms of Modern Japanese Sound Symbolic Words Not Listed in Dictionaries
Neuroscience and Biomedical Engineering (Discontinued)