Human Endogenous Retroviruses in Multiple Sclerosis: Potential for Novel Neuro-Pharmacological Research

Title: Human Endogenous Retroviruses in Multiple Sclerosis: Potential for Novel Neuro-Pharmacological Research

Volume: 9 Issue: 2

Author(s): F. P. Ryan

Affiliation:

Keywords: Multiple Sclerosis, autoimmunity, MS, human endogenous retroviruses, MS-associated retrovirus, MSRV, HERV-W, acute relapsing MS, secondary-progressive MS, human genome, genetic symbiogenesis

Abstract: There is growing evidence that the env genes of two or more human endogenous retroviruses (HERVs) of the W family are contributing to the inflammatory processes, and thus to the pathogenesis, of multiple sclerosis (MS). Increasing understanding of the human endogenous retroviral locus, ERVWE1, and the putative multiple sclerosis associated retrovirus, or MSRV, and in particular of the HERV-W env sequences associated with these, offers the potential of new lines of pharmacological research that might assist diagnosis, prognosis and therapy of multiple sclerosis.

Cite this article as:

P. Ryan F., Human Endogenous Retroviruses in Multiple Sclerosis: Potential for Novel Neuro-Pharmacological Research, Current Neuropharmacology 2011; 9 (2) . https://dx.doi.org/10.2174/157015911795596568