Strategies in Synthetic Radical Organic Chemistry. Recent Advances on Cyclization and SRN1 Reactions

Roberto   A.   Rossi; Alicia   B.   Penenory

doi:10.2174/157017906776819169

Abstract

Radical ring closure reactions by intramolecular addition of a radical to a tethered double bond afford a new cyclized radical intermediate that can be reduced, or further react with different reagents to yield substituted-cyclic compounds. The applications of SRN1 reactions are broad in scope, encompassing the utilization of poorly reactive substrates. We undertake a compilation to cover recent literature of these reactions and their synthetic applications.

Keywords: Ring closure, reduction, SRN1, radicals, radical anions, electron transfer

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Current Organic Synthesis

Title: Strategies in Synthetic Radical Organic Chemistry. Recent Advances on Cyclization and SRN1 Reactions

Volume: 3 Issue: 2

Author(s): Roberto A. Rossi and Alicia B. Penenory

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Keywords: Ring closure, reduction, SRN1, radicals, radical anions, electron transfer

Abstract: Radical ring closure reactions by intramolecular addition of a radical to a tethered double bond afford a new cyclized radical intermediate that can be reduced, or further react with different reagents to yield substituted-cyclic compounds. The applications of SRN1 reactions are broad in scope, encompassing the utilization of poorly reactive substrates. We undertake a compilation to cover recent literature of these reactions and their synthetic applications.

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Rossi A. Roberto and Penenory B. Alicia, Strategies in Synthetic Radical Organic Chemistry. Recent Advances on Cyclization and SRN1 Reactions, Current Organic Synthesis 2006; 3 (2) . https://dx.doi.org/10.2174/157017906776819169