PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

Title: PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

Volume: 12 Issue: 8

Author(s): MaLing Gou, XiaWei Wei, Ke Men, BiLan Wang, Feng Luo, Xia Zhao, YuQuan Wei and ZhiYong Qian

Affiliation:

Keywords: Biodegradable polymer, cancer, diagnostic agent, drug delivery system, gene delivery, nanoparticle, poly(-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers, vaccine, nano-precipitation method, chemotherapy

Abstract: Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(- caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.

Cite this article as:

Gou MaLing, Wei XiaWei, Men Ke, Wang BiLan, Luo Feng, Zhao Xia, Wei YuQuan and Qian ZhiYong, PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery, Current Drug Targets 2011; 12 (8) . https://dx.doi.org/10.2174/138945011795906642