Abstract
Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40 – 70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity
Keywords: Obesity, aCGH, chromosome, deletion, duplication, translocation, fluorescent in situ hybridization, CNV, congenital anomalies, growth retardation
Current Genomics
Title: Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature
Volume: 12 Issue: 3
Author(s): Majed J. Dasouki, Erin L. Youngs and Karine Hovanes
Affiliation:
Keywords: Obesity, aCGH, chromosome, deletion, duplication, translocation, fluorescent in situ hybridization, CNV, congenital anomalies, growth retardation
Abstract: Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40 – 70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity
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Cite this article as:
J. Dasouki Majed, L. Youngs Erin and Hovanes Karine, Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature, Current Genomics 2011; 12 (3) . https://dx.doi.org/10.2174/138920211795677930
DOI https://dx.doi.org/10.2174/138920211795677930 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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