Immunopathogenesis of Severe Asthma

Title: Immunopathogenesis of Severe Asthma

Volume: 17 Issue: 7

Author(s): Christopher E. Brightling, Sumit Gupta, Fay Hollins, Amanda Sutcliffe and Yassine Amrani

Affiliation:

Keywords: Asthma, eosinophils, mast cels, remodelling, phenotyping, physiology, immunopathogenesis, Lung, biomechanical, Epidermal growth, neutrophils, cytokines, Mesenchymal progenitors, fibrocytes, hyper-responsiveness, sub-phenotypes

Abstract: Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology. In this review we shall summarise the current knowledge of the immunopathogenesis of severe asthma integrated across multiple scales to provide the insights into the structure function relationships required to begin to unravel the complexity of severe asthma.

Cite this article as:

E. Brightling Christopher, Gupta Sumit, Hollins Fay, Sutcliffe Amanda and Amrani Yassine, Immunopathogenesis of Severe Asthma, Current Pharmaceutical Design 2011; 17 (7) . https://dx.doi.org/10.2174/138161211795429028