Abstract
Aromatic oligoamide foldamers whose helical structures were stabilized by intramolecular hydrogen bindings between consecutive units not only can mimic the secondary or tertiary structures of its natural counterparts but also provide alternative approaches to study the properties of biopolymers in artificial systems. Aromatic oligoamide foldamers are sequence-specific oligomers as demonstrated in peptides and DNA, while variation of orientation and size of aromatic monomers and lengths of oligomers can generate many foldamers with desirable structures and in turn lead to different properties. In this article, we illustrate the structure-property relationships of aromatic oligoamide foldamers reported by us and collaborators.
Keywords: Aromatic oligoamides, foldamers, hydrogen bonds, helices, helical capsules, self-assembly, helical structures, double helices, biological activities, selfassembly, Homodouble helices, Heterodouble helices, NMR spectroscopy, DMSO, NOESY, H DOSY, F NMR
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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