Selective Androgen Receptor Modulators in Drug Discovery: Medicinal Chemistry and Therapeutic Potential

Title: Selective Androgen Receptor Modulators in Drug Discovery: Medicinal Chemistry and Therapeutic Potential

Volume: 6 Issue: 3

Author(s): Rodolfo Cadilla and Philip Turnbull

Affiliation:

Keywords: SARMs, AR, modulation, tissue selectivity, testosterone, dihydrotestosterone, estradiol, hypogonadism

Abstract: Modulation of the androgen receptor has the potential to be an effective treatment for hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis, benign prostatic hyperplasia, and sexual dysfunction. Side effects associated with classical anabolic steroid treatments have driven the quest for drugs that demonstrate improved therapeutic profiles. Novel, non-steroidal compounds that show tissue selective activity and improved pharmacokinetic properties have been developed. This review provides an overview of current advances in the development of selective androgen receptor modulators (SARMs).

Cite this article as:

Cadilla Rodolfo and Turnbull Philip, Selective Androgen Receptor Modulators in Drug Discovery: Medicinal Chemistry and Therapeutic Potential, Current Topics in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/156802606776173456