Abstract
Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.
Keywords: Allergic contact dermatitis, skin sensitization, chemical, metalion, hapten, arnica, nickel, proteomics
Mini-Reviews in Medicinal Chemistry
Title: Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses
Volume: 6 Issue: 3
Author(s): Stefan F. Martin, Irmgard Merfort and Hermann-Josef Thierse
Affiliation:
Keywords: Allergic contact dermatitis, skin sensitization, chemical, metalion, hapten, arnica, nickel, proteomics
Abstract: Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.
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Martin F. Stefan, Merfort Irmgard and Thierse Hermann-Josef, Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073493
DOI https://dx.doi.org/10.2174/138955706776073493 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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