Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses

Title: Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses

Volume: 6 Issue: 3

Author(s): Stefan F. Martin, Irmgard Merfort and Hermann-Josef Thierse

Affiliation:

Keywords: Allergic contact dermatitis, skin sensitization, chemical, metalion, hapten, arnica, nickel, proteomics

Abstract: Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.

Cite this article as:

Martin F. Stefan, Merfort Irmgard and Thierse Hermann-Josef, Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073493