Abstract
Three different approaches were employed to assess various markers associated with sex differences in responses to methamphetamine (MA). Bioassay measures reveal that MA treatment results in significantly greater reductions in body weight and increases in body temperature in male mice. Protein and mRNA determinations show significant increases in Bcl-2 and PAI-1 in male mice, while females show significant increases in GFAP and decreases in IGF-1R following treatment with MA. In mice with a heterozygous mutation of their dopamine transporter (+/- DAT), only female mice show significant differences in dopamine transporter binding and mRNA and associated reductions in striatal dopamine content along with increases in MA-evoked striatal dopamine output. The identification of these sex-dependent differences in markers provides a foundation for more exhaustive evaluation of their impact upon, and treatment of, disorders/neurotoxicity of the nigrostriatal dopaminergic system and the bases for the differences that exist between females and males.
Keywords: Body Weight, Body Temperature, GFAP, Bcl-2 PAI-1, IGF-1R, Dopamine Transporter, Body Weight, Body Temprature, Bcl-2 PAI, IGF-IR, Methamphetamine (MA), dihyroxyphenylacetic acid (DOPAC), Neurotoxicity, PAKT, GSK3 B, mRNA
Current Neuropharmacology
Title: Markers Associated with Sex Differences in Methamphetamine-Induced Striatal Dopamine Neurotoxicity
Volume: 9 Issue: 1
Author(s): D. E. Dluzen, J. L. McDermott, M. Bourque, T. Di Paolo, A. S. Darvesh, A. B. Buletko and N. J. Laping
Affiliation:
Keywords: Body Weight, Body Temperature, GFAP, Bcl-2 PAI-1, IGF-1R, Dopamine Transporter, Body Weight, Body Temprature, Bcl-2 PAI, IGF-IR, Methamphetamine (MA), dihyroxyphenylacetic acid (DOPAC), Neurotoxicity, PAKT, GSK3 B, mRNA
Abstract: Three different approaches were employed to assess various markers associated with sex differences in responses to methamphetamine (MA). Bioassay measures reveal that MA treatment results in significantly greater reductions in body weight and increases in body temperature in male mice. Protein and mRNA determinations show significant increases in Bcl-2 and PAI-1 in male mice, while females show significant increases in GFAP and decreases in IGF-1R following treatment with MA. In mice with a heterozygous mutation of their dopamine transporter (+/- DAT), only female mice show significant differences in dopamine transporter binding and mRNA and associated reductions in striatal dopamine content along with increases in MA-evoked striatal dopamine output. The identification of these sex-dependent differences in markers provides a foundation for more exhaustive evaluation of their impact upon, and treatment of, disorders/neurotoxicity of the nigrostriatal dopaminergic system and the bases for the differences that exist between females and males.
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Cite this article as:
E. Dluzen D., L. McDermott J., Bourque M., Di Paolo T., S. Darvesh A., B. Buletko A. and J. Laping N., Markers Associated with Sex Differences in Methamphetamine-Induced Striatal Dopamine Neurotoxicity, Current Neuropharmacology 2011; 9 (1) . https://dx.doi.org/10.2174/157015911795017399
DOI https://dx.doi.org/10.2174/157015911795017399 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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