Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study

S.   M.   Fiuza; A.   M.   Amado; Paulo   J.   Oliveira; Vilma   A.   Sardao; L.   A.E.B.   de Carvalho; M.   P.M.   Marques

doi:10.2174/157018006776286989

Abstract

Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).

Keywords: Pt(II), Pd(II), spermidine, anticancer drugs, squamous tongue epithelioma

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Letters in Drug Design & Discovery

Title: Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study

Volume: 3 Issue: 3

Author(s): S. M. Fiuza, A. M. Amado, Paulo J. Oliveira, Vilma A. Sardao, L. A.E.B. de Carvalho and M. P.M. Marques

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Keywords: Pt(II), Pd(II), spermidine, anticancer drugs, squamous tongue epithelioma

Abstract: Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).

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Fiuza M. S., Amado M. A., Oliveira J. Paulo, Sardao A. Vilma, de Carvalho A.E.B. L. and Marques P.M. M., Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study, Letters in Drug Design & Discovery 2006; 3 (3) . https://dx.doi.org/10.2174/157018006776286989