Abstract
The tetracyclic heteroaromatic compounds cryptolepine, isocryptolepine and neocryptolepine are all naturally occurring indoloquinoline alkaloids isolated from the shrub Cryptolepis sanguinolenta and are important due to their wide spectrum of biological properties. This review describes the isolation, brief biological activities and various synthetic methodologies developed during recent years for the preparation of this important class of alkaloids, with special emphasis on preparation and properties of cryptolepine 1, isocryptolepine 2 and neocryptolepine 3.
Keywords: Alkaloid, cryptolepine, heteroaromatic, indoloquinoline, isocryptolepine, neocryptolepine, tuberculosis, AIDS, Ghana-strain, spectroscopy, Palladium-catalyzed Coupling Reaction, regioselective coupling reaction, Suzuki arylation, Myers method, Aza-Wittig Reaction
Current Organic Chemistry
Title: Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine
Volume: 15 Issue: 7
Author(s): Prakash T. Parvatkar, Perunninakulath S. Parameswaran and Santosh G. Tilve
Affiliation:
Keywords: Alkaloid, cryptolepine, heteroaromatic, indoloquinoline, isocryptolepine, neocryptolepine, tuberculosis, AIDS, Ghana-strain, spectroscopy, Palladium-catalyzed Coupling Reaction, regioselective coupling reaction, Suzuki arylation, Myers method, Aza-Wittig Reaction
Abstract: The tetracyclic heteroaromatic compounds cryptolepine, isocryptolepine and neocryptolepine are all naturally occurring indoloquinoline alkaloids isolated from the shrub Cryptolepis sanguinolenta and are important due to their wide spectrum of biological properties. This review describes the isolation, brief biological activities and various synthetic methodologies developed during recent years for the preparation of this important class of alkaloids, with special emphasis on preparation and properties of cryptolepine 1, isocryptolepine 2 and neocryptolepine 3.
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Cite this article as:
T. Parvatkar Prakash, S. Parameswaran Perunninakulath and G. Tilve Santosh, Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine, Current Organic Chemistry 2011; 15 (7) . https://dx.doi.org/10.2174/138527211794785118
DOI https://dx.doi.org/10.2174/138527211794785118 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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