Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions

Title: Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions

Volume: 10 Issue: 1

Author(s): Ceng Luo, Rou-Gang Xie and San-Jue Hu

Affiliation:

Keywords: Inflammation, pain, prostaglandins, proinflammatory cytokines, hyperalgesia, bradykinin, COX, Tetrodotoxin (TTX) resistant, Tumor- necrosis factor- alpha (TNF- ), GlucocortiCoids

Abstract: Pain and inflammation are considered strongly associated. The greater pain behavior was demonstrated in animals with greater amount of inflammation. Tissue or nerve injury results in the release of various inflammatory mediators such as prostaglandins, bradykinin, proinflammatory cytokines, chemokines, histamine, serotonin and nerve growth factors from the site of injury. These inflammatory mediators play a critical role in both integrating the inflammatory response and mediating pain hypersensitivity. This review highlights the role of prostaglandins and proinflammatory cytokines in the pain sensitization and its underlying mechanisms, emphasizing the evidence that these molecules are potential targets to develop novel drugs and therapies for the treatment of both inflammation and pain in clinic.

Cite this article as:

Luo Ceng, Xie Rou-Gang and Hu San-Jue, Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (1) . https://dx.doi.org/10.2174/187152311795325497