Applications of Arterial Spin Labelling in Mild Cognitive Impairment, Alzheimers Disease and Other Forms of Dementia

Title: Applications of Arterial Spin Labelling in Mild Cognitive Impairment, Alzheimers Disease and Other Forms of Dementia

Volume: 7

Author(s): Norbert Schuff

Affiliation:

Keywords: Magnetic resonance imaging, cerebral blood flow, Alzheimer's disease, mild cognitive impairment, ASL- MRI, CASL, PASL, MCI, PET, FTD

Abstract: The development of an accurate marker for Alzheimers disease (AD) at the earliest stage is an important public health goal. Modern neuroimaging techniques offer one potential approach to identify a marker for AD. This review focuses on the detection of alterations in brain perfusion as a potentially sensitive index of AD pathology using arterial spin labeling (ASL) perfusion mapping – a relatively new variant of magnetic resonance imaging (MRI). Key findings of ASL perfusion studies in AD mild cognitive impairment (MCI), a transitional stage between normal aging and AD as well as in other forms of dementia are discussed. Furthermore, the value of ASL-MRI for improved diagnosis and prediction of AD is critically reviewed.

Cite this article as:

Schuff Norbert, Applications of Arterial Spin Labelling in Mild Cognitive Impairment, Alzheimers Disease and Other Forms of Dementia, Current Medical Imaging 2011; 7 (1) . https://dx.doi.org/10.2174/157340511794653487

DOI https://dx.doi.org/10.2174/157340511794653487	Print ISSN 1573-4056
Publisher Name Bentham Science Publisher	Online ISSN 1875-6603