Abstract
The inflammatory response is the reaction of all Metazoan organisms to pathogen invasion that initiates when pathogenderived molecules are recognized by specific pattern recognition receptors expressed mainly on cells of the innate immune system. The successive expression of pro-inflammatory cytokines and chemokines limits pathogen spread, and attracts and activates immune cells to help in the elimination of the invaders. In this paper we focused on the analyses of the 3D structures of three pro-inflammatory molecules (interleukin-1β, tumor necrosis factor-α, interleukin-8) from selected Teleost fish species (Oncorhynchus mykiss, Dicentrarchus labrax, Chionodraco hamatus) generated using as template models those of experimental homologous proteins. These structures were discussed with the aim to investigate the differences between them and mammalian counterparts and, moreover, to verify the presence of the structural requirements for their biological activities, known mainly in mammals.
Keywords: Teleosts, 3D modelling, IL-1, TNF, IL-8, evolution, biological activity
Current Pharmaceutical Design
Title: 3D Modelling of Three Pro-Inflammatory Molecules in Selected Fish Species
Volume: 16 Issue: 38
Author(s): Susan Costantini, Angelo M. Facchiano, Elisa Randelli, Daniela Casani, Giuseppe Scapigliati and Francesco Buonocore
Affiliation:
Keywords: Teleosts, 3D modelling, IL-1, TNF, IL-8, evolution, biological activity
Abstract: The inflammatory response is the reaction of all Metazoan organisms to pathogen invasion that initiates when pathogenderived molecules are recognized by specific pattern recognition receptors expressed mainly on cells of the innate immune system. The successive expression of pro-inflammatory cytokines and chemokines limits pathogen spread, and attracts and activates immune cells to help in the elimination of the invaders. In this paper we focused on the analyses of the 3D structures of three pro-inflammatory molecules (interleukin-1β, tumor necrosis factor-α, interleukin-8) from selected Teleost fish species (Oncorhynchus mykiss, Dicentrarchus labrax, Chionodraco hamatus) generated using as template models those of experimental homologous proteins. These structures were discussed with the aim to investigate the differences between them and mammalian counterparts and, moreover, to verify the presence of the structural requirements for their biological activities, known mainly in mammals.
Export Options
About this article
Cite this article as:
Costantini Susan, M. Facchiano Angelo, Randelli Elisa, Casani Daniela, Scapigliati Giuseppe and Buonocore Francesco, 3D Modelling of Three Pro-Inflammatory Molecules in Selected Fish Species, Current Pharmaceutical Design 2010; 16 (38) . https://dx.doi.org/10.2174/138161210794519129
DOI https://dx.doi.org/10.2174/138161210794519129 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat's Basic Region
Current HIV Research Substrate Phage as a Tool to Identify Novel Substrate Sequences of Proteases
Combinatorial Chemistry & High Throughput Screening Modulation of Collagen Turnover in Cardiovascular Disease
Current Pharmaceutical Design Fatty Acid Amide Hydrolase: A Potential Target for Next Generation Therapeutics
Current Pharmaceutical Design DNA Topoisomerases in Life and Death: Implications in Kinetoplastid Protozoa
Current Molecular Medicine Management of Liver Disease in Thalassemia: Main Drug Targets for a Correct Therapy
Current Drug Targets - Immune, Endocrine & Metabolic Disorders In the Search of the Vulnerable Plaque: Current Diagnostic Techniques and Future Directions
Vascular Disease Prevention (Discontinued) The Inflammatory Milieu of the Degenerate Disc: Is Mesenchymal Stem Cell-based Therapy for Intervertebral Disc Repair a Feasible Approach?
Current Stem Cell Research & Therapy Anti-inflammatory Potential of Alkaloids as a Promising Therapeutic Modality
Letters in Drug Design & Discovery Cytomegalovirus Infection in Pediatric Immunocompromised Hosts
Infectious Disorders - Drug Targets CD93: Recent Advances and Implications in Disease
Current Drug Targets Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases
Mini-Reviews in Medicinal Chemistry A Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab) in the Therapy of Moderate-to-Severe Allergic Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression
Current Drug Targets Coenzyme Q10 Attenuates Cisplatin-induced Nephrotoxicity Through Counteracting Oxidative Stress and Inflammation
Clinical Cancer Drugs Bothrops pauloensis Snake Venom Toxins: The Search for New Therapeutic Models
Current Topics in Medicinal Chemistry Yokukansan, a Japanese Herbal Medicine, Suppresses Substance P-Induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets SARS: Understanding the Virus and Development of Rational Therapy
Current Molecular Medicine Engineering of Nanoemulsions for Drug Delivery
Current Drug Delivery Therapeutic Targeting of Developmental Signaling Pathways in Medulloblastoma: Hedgehog, Notch, Wnt and Myc
Current Signal Transduction Therapy