Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Hua      Lu; Haixia      Lin; Yi      Jiang; Xinguang      Zhou; Beili      Wu; Jianmin      Chen

doi:10.2174/157018006775789757

Abstract

A series of new 20-O-linked succinate-based camptothecin ester derivatives were synthesized and their cytotoxicities were tested on five human cancer cell lines by MTT assay. All the derivatives showed moderate antitumor activity in vitro, and they were 20-to-several thousand-fold less toxic than their parent drug.

Keywords: Camptothecin, ester, succinate, prodrug, antitumor

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Letters in Drug Design & Discovery

Title: Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Volume: 3 Issue: 2

Author(s): Hua Lu, Haixia Lin, Yi Jiang, Xinguang Zhou, Beili Wu and Jianmin Chen

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Keywords: Camptothecin, ester, succinate, prodrug, antitumor

Abstract: A series of new 20-O-linked succinate-based camptothecin ester derivatives were synthesized and their cytotoxicities were tested on five human cancer cell lines by MTT assay. All the derivatives showed moderate antitumor activity in vitro, and they were 20-to-several thousand-fold less toxic than their parent drug.

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Lu Hua, Lin Haixia, Jiang Yi, Zhou Xinguang, Wu Beili and Chen Jianmin, Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789757