Contribution of Inflammation to Fat Redistribution and Metabolic Disturbances in HIV-1 Infected Patients

Title: Contribution of Inflammation to Fat Redistribution and Metabolic Disturbances in HIV-1 Infected Patients

Volume: 16 Issue: 30

Author(s): Metodi V. Stankov and Georg M.N. Behrens

Affiliation:

Keywords: Antiretroviral therapy, HIV-1, fat redistribution, metabolic syndrome, chronic inflammation

Abstract: Antiretroviral therapy (ART) has significantly reduced the morbidity and mortality of patients infected with the human immunodeficiency virus 1 (HIV-1). In a significant number of patients, ART is associated with fat redistribution and metabolic alterations such as dyslipidemia, insulin resistance (IR) and type 2 diabetes, summarized under the term HIV-associated lipodystrophy syndrome (HIVLS). The pathogenesis of HIV-LS is complex and involves a number of factors including ART, HIV-1, abnormal fat redistribution, metabolic abnormalities and chronic inflammation. In view of a novel understanding on how chronic inflammation contributes to the pathogenesis of HIV-1 infection, this review focuses on the interaction of the immune system and metabolic pathways and the potential consequences for the HIV-LS. Based on the current literature, we suggest a central role of systemic inflammation in triggering and deteriorating various components of the HIV-LS.

Cite this article as:

V. Stankov Metodi and M.N. Behrens Georg, Contribution of Inflammation to Fat Redistribution and Metabolic Disturbances in HIV-1 Infected Patients, Current Pharmaceutical Design 2010; 16 (30) . https://dx.doi.org/10.2174/138161210793563473