Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

Oleg   Y.   Sokolov; Natalya   V.   Kost; Yurii   A.   Zolotarev; Ekaterina   N.   Ryukert; Andrey   A.   Zozulya

doi:10.2174/092986606775101733

Abstract

Using radio-receptor analysis, it has been demonstrated that human ε-casomorphin-7 (Tyr-Pro-Phe-Val- Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human β-casomorphin-7 was 8 μM. These data suggest that one of the mechanisms of neurotropic action of β-casomorphin-7 is might be associated with its influence on the serotoninergic system.

Keywords: Human β-Casomorphin-7, 5-HT2-receptors, spiperone

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Protein & Peptide Letters

Title: Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

Volume: 13 Issue: 2

Author(s): Oleg Y. Sokolov, Natalya V. Kost, Yurii A. Zolotarev, Ekaterina N. Ryukert and Andrey A. Zozulya

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Keywords: Human β-Casomorphin-7, 5-HT2-receptors, spiperone

Abstract: Using radio-receptor analysis, it has been demonstrated that human ε-casomorphin-7 (Tyr-Pro-Phe-Val- Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human β-casomorphin-7 was 8 μM. These data suggest that one of the mechanisms of neurotropic action of β-casomorphin-7 is might be associated with its influence on the serotoninergic system.

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Sokolov Y. Oleg, Kost V. Natalya, Zolotarev A. Yurii, Ryukert N. Ekaterina and Zozulya A. Andrey, Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex, Protein & Peptide Letters 2006; 13 (2) . https://dx.doi.org/10.2174/092986606775101733