Nanomaterials: New Generation Therapeutics in Wound Healing and Tissue Repair

Ajay      V. Singh; Aditi      A.S; W.      N. Gade; Tanushree      Vats; Cristina      Lenardi; Paolo      Milani; Aditi      A.S.

doi:10.2174/157341310793348632

Abstract

Wound healing and ulcer management is a vast topic that stimulated clinical research due to its major socio economic impact on clinical practices. Last decade of research in clinical science has seen materials at microscale developments which significantly contributed to ulcer management and wound healing with their merits and limitations. The present review outlines the new materials at nanoscale that have been designed and manufactured to address the existing problems in wound care but comparatively less familiar to clinicians for tissue repair and ulcer management. Development in tissue engineering practices spanning from micro- to nano- dimension provided superior materials over traditional wound dressing materials mimicking tissue in vivo. Recent advances in material sciences and polymer chemistry have yielded an entire class of new nanomaterials, ranging from bioactive tissue scaffold to novel electrospun polymer and hydrogel for tissue repair and wound management. Nanoscale materials with biodegradable chemistries and molecular compositions assist wound healing as adhesive and bandages in specialized wound care. Moreover, new class of materials gives opportunity to engineer tissue substrate in vitro to support bio-responsive nanomedicine for wound healing. Soft nanomaterial design technology involving hydrogel and bio-scaffold revolutionized the wound management supplementing biophysical and biochemical considerations of tissue regeneration. In addition, this review addresses the immediate challenges and opportunities provided by nanoscale tissue engineering in designing synthetic biomaterials as instructive extracellular matrix (ECM) for tissue remodeling and morphogenesis.

Keywords: Hydrogel, wound bed preparation, electrospinning, multidrug resistance, dendrimer, ulcer management, ECM, wounds, cytokines, WBP, (3-D) structures, MDR, NPs, S/V, Hydrogels, Hydrophilicity, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, PEG, SA, PLA, FNfds, HA, PDGFs, GFs, Dextrin, –, rhEGF conjugates, trypsin, NTCAS, SAP, EGF, CNTs, ACTICOAT, SILCRYSTTM, MRSA, glycoproteins