Abstract
Efforts have been made to understand the underlying mechanism and stereochemistry for the observed enantio- and diastereoselectivities in various chiral amine catalyzed Mannich reactions with special reference to proline and its analogous derivatives. Substrate scope in Mannich reaction tunable by structural modification in acceptor and donor components, recent examples, developments, and applications are discussed.
Keywords: Asymmetric organocatalysis, mannich reaction, stereoselective synthesis, absolute configuration, proline, organocatalysis, reaction, stereoselective, absolute, amino-carbonyl, acyclic chiral amines, anti-selectivity, hydroxyketones, amination, oxidation, aldol reactions, (PMP), (E)-aldimine, L-proline, syn-adduct, enantioselectivity, N-Boc-imines, enantiomer, acetaldehyde, drug intermediates, chiral amino acids, amino acids, anti-(E)-enamine, Proline Deri-vatives, DMSO
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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