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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Stability and Drug Metabolism Assessed by Electrochemical Methods

Author(s): Alejandro Alvarez-Lueje and Soledad Bollo Dragnic

Volume 13, Issue 8, 2010

Page: [712 - 727] Pages: 16

DOI: 10.2174/138620710791920329

Price: $65

Abstract

This review is focused on the use of the electrochemical techniques, voltammetry and polarography, as well as biosensors, for the study of drug stability. In addition, this review also details the study of drug metabolism by electrochemistry and mass spectrometry. This is used as a tool to mimic drug metabolism and because it is a purely instrumental method, may have advantages over, or be complementary to, the existing biological assays.

Keywords: Drug, stability, metabolism, voltammetry, polarography, biosensors, electrochemistry-mass spectrometry


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