Abstract
It is now well known that non-aqueous biocatalysis has emerged as an important area of systematic research and industrial development over the last two decades, fueled mainly by chemical and pharmaceutical interest. The non-aqueous biocatalysis boasts many potential advantages, including higher substrate solubility, reversal of hydrolytic reactions and modified enzyme specificity. As a consequence, applications of enzymatic catalysis in organic solvents range from chiral resolution of pharmaceuticals and their intermediates to enantio- or regio-selective synthesis of these substances. In this review, recent trends of biocatalyst engineering and solvent engineering in non-aqueous biocatalysis, diversified enzyme reactions for non-aqueous biocatalysis and a greener need for it have been discussed in detail with new examples.
Keywords: Non-aqueous biocatalysis, Biphasci reaction, Lipase, Reductase, Oxidizing enzyme, Ionic liquids, Green chemistry
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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